![]() ![]() MDMA was found to induce significant and robust attenuation in CAPS-5 score compared with placebo (P < 0.0001, d = 0.91) and to significantly decrease the SDS total score (P = 0.0116, d = 0.43). Adverse events and suicidality were tracked throughout the study. PTSD symptoms, measured with the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5, the primary endpoint), and functional impairment, measured with the Sheehan Disability Scale (SDS, the secondary endpoint) were assessed at baseline and at 2 months after the last experimental session. After psychiatric medication washout, participants (n = 90) were randomized 1:1 to receive manualized therapy with MDMA or with placebo, combined with three preparatory and nine integrative therapy sessions. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial ( NCT03537014) to test the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for the treatment of patients with severe PTSD, including those with common comorbidities such as dissociation, depression, a history of alcohol and substance use disorders, and childhood trauma. Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. 27 Department of Neurology, University of California San Francisco, San Francisco, CA, USA.26 Stanford School of Medicine, Stanford, CA, USA.25 Be'er Ya'akov Ness Ziona Mental Health Center, Be'er Ya'akov, Israel.24 Dr Simon Amar Inc., Montreal, Quebec, Canada.23 University of Toronto, Toronto, Ontario, Canada.22 Zen Therapeutic Solutions, Mt Pleasant, SC, USA.21 New School Research LLC, North Hollywood, CA, USA.20 Wholeness Center, Fort Collins, CO, USA.19 Ray Worthy Psychiatry LLC, New Orleans, LA, USA.18 Chaim Sheba Medical Center, Tel HaShomer, Israel. ![]() 17 Boston University School of Medicine, Boston, MA, USA.16 British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada.15 San Francisco Insight and Integration Center, San Francisco, CA, USA.14 Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.13 Medical University of South Carolina, Charleston, SC, USA.12 Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.10 Nautilus Sanctuary, New York, NY, USA.9 MDMA Therapy Training Program, MAPS Public Benefit Corporation, San Jose, CA, USA.8 Aguazul-Bluewater Inc., Boulder, CO, USA.7 KPG Psychological Services LLC, Brunswick, ME, USA.6 Kleiman Consulting and Psychological Services, Sayreville, NJ, USA.5 MAPS Public Benefit Corporation (MAPS PBC), San Jose, CA, USA.4 Multidisciplinary Association for Psychedelic Studies (MAPS), San Jose, CA, USA.3 Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA. 2 Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA. 1 Department of Neurology, University of California San Francisco, San Francisco, CA, USA.Our agency has the exciting job of promoting employers and helping people find these opportunities through projects such as our rural initiative,” concluded Floyd. “We are fortunate to live in a state that is growing and has so many opportunities for work. “Our first week on the road will include the following stops:ġ001 North Main Street, Mullins, SC 29574 DEW Leadership, workforce consultants, business engagement professionals, labor market information experts, SC Works representatives, local leaders, and employers will participate in these events,” said Floyd. This rural initiative includes our agency, the SC Works Career Coach, and partners traveling around the state to set up community job fairs in rural counties. Our Road Trips are one way that we will accomplish just that. “As our workforce continues to thrive, DEW is committed to spending the rest of 2023 proactively engaging rural communities to help people find work and employers find their workers. With that, the labor force participation rate jumped to 56.1% from February’s rate of 55.9%.” “The state also saw an increase of more than 11,000 people in the labor force month-over-month. Department of Employment and Workforce (DEW) Acting Executive Director William Floyd. – “South Carolina is continuing to progress with a record high of 2,316,712 people working in South Carolina and a stable unemployment rate of 3.2%, unchanged from February,” said S.C. Employment and Workforce Acting Executive Director William Floyd’s StatementĬolumbia, S.C. ![]()
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